New Glasgow is a thriving combination of small, mid-size and large businesses. There are several commercial, service and business districts in the town, which include the Downtown core, Westville Road, East River Road, Stellarton Road and a Business Park in the Parkdale area.
New Glasgow is also home to the Maritimes Northeast Pipelines central office, Stright-McKay, SW Weeks Construction, Ballantyne Fuels, I Matheson, the Aberdeen Regional Hospital, a Web.com Canada Operations Centre, three Sobeys grocery stores, Crombie REIT head office, the Atlantic Superstore,  New Glasgow Farmers Market, the regional Library headquarters as well as Highland Square Mall, most major car dealership and major financial institutions.